Endocrine Abstracts

We have previously demonstrated that ERβ is necessary for embryonic development of the brain as early as E14.5 and is involved in neuronal migration. Such early effects of estrogen receptors were unexpected because estradiol synthesis and action in the brain are well documented to occur at E18.5.Since the presence of ERβ in the embryonic brain has not been demonstrated, it remained possible that the developmental abnormalities in ERβ−/− mi...